الفهرس 
IRRITABLE BOWEL SYNDROMEOnly 14 pages are availabe for public view
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Abstract
I
rritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disease that significantly affects patient quality of life, interfere with daily activities, physical intimacy, traveling, and self-esteem. Because of its clinical heterogeneity and the unclear etiology of IBS, robust biomarkers and therapeutic targets for IBS are difficult to identify. On the other side, Non-alcoholic fatty liver disease (NAFLD) has become a common disease worldwide, affecting 25% of the adult population.
The aim of the study is to detect if there is a prevalent relation between those two diseases and the assessment of NAFLD prevalence and severity in IBS patients.
Our study has involved 75 patients with different degrees of IBS syndrome and variable severity patterns of NAFLD. Using inclusion and exclusion criteria for selecting the patients; IBS diagnosed according to modified ROME IV criteria regardless of the type either constipation predominance or diarrhea predominance. While NAFLD was mainly detected using abdominal ultrasonography, both were differentiated into three grades determining the severity of each and their correlation.
The current study included 75 patients diagnosed with IBS (37 males and 38 females). Mean age of included patients was 42.17 ± 8.3 years. Mean height of included patients was 173.6 ± 9.07 cm, mean weight was 88.02 ± 14.9 Kg while mean BMI was 29.39 ± 4.4.
Results revealed regarding evaluating the association of IBS with NAFLD there were high statisitical significant assocaiton between both diseases. The study of lipid profile parameters and liver enzymes in relation to IBS grade revealed no-significant association. The study of IBS grade regarding liver enzymes revealed no significant statistical difference between grades of IBS. Study of lipid profile parameters (S. Cholesterol, S. Triglycerides and LDL) in relation to ultrasonography grade revealed high significant association between increased serum triglycerides and severe grade of NAFLD.
Based on our study, we found that patients with IBS had higher frequency of NAFLD. Also, there is significant association between IBS and NAFLD severity. So, patients with IBS should be frequently monitored to assess the presence of NAFLD: Frequent clinical evaluation, abdominal ultrasonography in addition to Lipid profile and liver functions tests assessment if needed.
Although we could not exclude the psychological element as a confounder which is needed to be taken into consideration in following studies, the study patients were not subjected to psychological assessment, In addition our results need to be confirmed by a further trials with a larger sample size, but also, there are few studies as far as we know, to explore the impact of NAFLD on the severity of IBS.