الفهرس 
C HRONIC K IDNEY D ISEASE (Only 14 pages are availabe for public view
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Abstract
Background: chronic kidney disease (CKD) is a major public health problem worldwide and is associated with a considerable increase in morbidity and mortality, cardiovascular disease is most common cause of death among chronic kidney disease patients.
Objectives: The aim of study was to determine the association between serum ADMA level and cardiac functions assessed by tissue Doppler imaging in chronic kidney disease patients.
Patients and methods: our study conducted on 90 patients from outpatient clinic or inpatient department of national institute of nephrology and urology. All patients were subjected to full history, full clinical examination, laboratory investigations including: serum urea, serum albumin, complete blood picture, serum electrolytes (calcium and phosphorus), PTH, serum ADMA, lipid profile and echocardiography and Tissue Doppler imaging.
Results: 90 patients were included in the study. Each group consisted of 30 patients stage 3, 4, and, 5 non-dialysis patients. Mean age of stage 3, stage 4, and stage 5 non-dialysis CKD patients were respectively 42.33 years, 39.77 years and 38.67 years. The mean levels of ADMA in stage 3, stage 4, and 5 were 12701 ng/mL, 14853 ng/mL, and18481 ng /mL respectively. Analysis of the differences between the groups showed significant differences in ADMA levels (p=0.037), as ADMA level increase with progression of disease.
Conclusion: Serum ADMA is negatively correlated with diastolic function among CKD patients,, Tissue Doppler imaging is more accurate than echocardiography to estimate diastolic function.