الفهرس 
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Abstract
RA is a multi-system disorder with joint inflammation, which causes patients chronic pain, disability and increased mortality.
Leptin was initially described as a hormone that regulated food intake and energy balance and it is a mediator of the inflammatory process. leptin is a master regulator of the immune system. Disequilibrium in circulating levels and dysregulation of its secretion by white adipose tissue as well as by other peripheral tissues, can impair immune function and the integrity of a correct immune response
Numerous data support the key role of leptin in immunity and autoimmune diseases. Prevailing studies suggest that leptin is of great importance in the pathogenesis of RA.
Blocking the key signal pathways of leptin and inhibiting leptin activity, such as with leptin antagonists, may be a promising way for the therapeutic potential of RA at risk of detrimental effects. Hence, further understanding of the mechanism of leptin would be advantageous in the future in RA treatment.