الفهرس 
KeloidOnly 14 pages are availabe for public view
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Abstract
Background: Keloids are fibrous lesions that form at a site of injury due to
irregular production of types I and III collagen. Thymidylate synthase (TS) is
essential for DNA synthesis and repair, and its absence blocks proliferation and
causes cell death. 5-Fluorouracil is a fluorinated pyrimidine analog that acts as
an anti-metabolic agent, inhibiting thymidylate synthase and interfering with
RNA synthesis.
Objectives: The aim of our study was to evaluate the level of thymidylate
synthase in keloid patients before and after intralesional injection of 5 -
fluorouracil.
Methods: The study included 20 keloid patients and 20 healthy subjects as a
control. Serum TS was estimated using commercially available Enzyme-linked
immunosorbant assay (ELISA) kits before and after treatment with 5 -
fluorouracil.
Results: There was statistically significant difference in TS levels before and
after 5FU treatment (p<0.05). Also our results revealed that 5‐FU injection has
good satisfactory results in treatment of keloid .It showed reduction in the scar
volume and improvement of the symptoms (90% of the patients improved). On
the other hand, there was no statistically significant difference in TS levels and
the outcomes of the treatment.
Conclusion: Our findings suggest that intralesional 5‐FU injection in keloid has
very satisfactory results. However, thymidylate synthase enzyme has a minimal
role in evaluating the treatment of keloid, so further studies is required to
elaborate the relation between this enzyme and keloid scar.
Key Words: Keloid- Thymidylate synthase -5-Fluorouracil.