الفهرس 
ContentsOnly 14 pages are availabe for public view
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Abstract
Multi Parametric Magnetic Resonance Imaging and Visceral Adiposity Index as New Diagnostic Tools of Non Alcoholic Fatty Liver Disease (NAFLD)” Introduction : Non-invasive assessment of non-alcoholic fatty liver disease (NAFLD) is increasing in desirability due to the invasive nature and costs associated with the current form of assessment by liver biopsy. Multi-parametric MRI and visceral adiposity index are an emerging alternative which could be utilized as safe surrogate to liver biopsy. Aim of work : The aim of this study is to evaluate the diagnostic utility of multi-parametric MRI for hepatic steatosis in patients having NAFLD. Patients and methods sixty patients with NAFLD were recruited into this cross-sectional study and were screened using non-invasive imaging technique; mpMRI. Patients were biopsied, and samples were scored by one expert hepato-pathologist. The diagnostic performance of mpMRI was assessed using area under receiver operating characteristic curve (AUC) with the median of the histology scores as the gold standard diagnoses. Results and discussion. AUROC for MRS-PDFF was 1.000 (p =0.0001; 95% CI = 1.000–1.000), a cut-off value of 32.5 had the best sensitivity (97.5%) and specificity (100%).The AUROC for FF index was 0.995 (p =0.0001; 95% CI = 1.000–0.985), a cut-off value of 22.5 had the best sensitivity (97.2%) and optimal specificity (84%). The AUROC for WF index was 0.998 (p =0.0001; 95% CI = 1.000–0.991), a cut-off value of 22.5 had the best sensitivity (97.2%) and optimal specificity (92%). Summary & conclusions : This study suggests that multi-parametric MRI can be used as a non-invasive substitute to liver biopsy as regard diagnosis & grading of hepatic steatosis and detection of steatohepatitis in patients with NAFLD, While, VAI cannot be used as a dependable predictor of hepatic steatosis, steatohepatitis or fibrosis.