الفهرس 
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Abstract
This study was conducted to assess the importance of MRI in the preoperative diagnosis and management of patients affected by lobular carcinoma in-situ and invasive lobular carcinoma. This study included 47 female patients with age range of 26 - 64 years who were presented at Oncology department, general surgery department and Radio-diagnosis Department-Mansoura University, Egypt. After obtaining a written informed consent, the cases were subjected to full history taking and full clinical examination including careful assessment of the axilla and axillary LNs. MRI examination of the breast was performed for all patients using a 1.5 Tesla machine. The process of image acquisition by MRI included localizing sagittal protocol (scout view), T1-weighted pulse sequence, Short TI inversion recovery (STIR) and the dynamic study. MRI findings have been correlated with standard of reference which is the results of the histo- pathological studies either after open or closed biopsy. Out of 47 patients underwent surgery, 30 patients had a true cut biopsy before surgery and 17 had open surgery biopsy. • The mean age in the cases was 47.34±10.53 years. • The higher percentage of the included cases showed negative family history (78.7%) and no use of contraception (76.6%). • The most common presentation among the included cases was palpable mass (48.9 %) followed by post NAC assesement (12.8 %). • The majority of cases showed absent skin lesions (68%) and absent nipple affection (82.9%). • The axillary lymph nodes were affected in 78.7% of the cases. • There were 4 cases (8.5%) with lobular carcinoma in situ while there 43 cases (91.5%) with invasive lobular carcinoma. • Among the cases, there were 40.4% of the studied cases BIRADS 6, 36.2% BIRADS 4 and 23.4% BIRADS 5. • There was significant lower mean ADC among cases with LCIS than cases with ILC. • The best cutoff point of ADC to differentiate ILC cases from LCIS was 0.824 yielding sensitivity of 97.5% , specificity 71.4% and accuracy 93.6% • Among the included cases, 63.8% of cases have radical management while 36.2% of cases had conservative management.