الفهرس 
review of literatureOnly 14 pages are availabe for public view
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Abstract
Fibrosis is a common pathological process for the majority of liver diseases which in a significant minority of patients leads to end-stage cirrhosis and/or hepatocellular carcinoma.
Hepatic fibrosis, the principal pointer to the development of a liver disease within chronic hepatitis C, can be measured through several stages. The correct evaluation of its degree, based on recent different non-invasive procedures, is of current major concern.
We can recommended that, using of (matrix metalloproteinase-8, Galectin-3 and urokinase plasminoge activator a simple and non-invasive biochemical markers for the assessment of different stages of hepatic fibrosis as alternatives to liver biopsy which is invasive, expensive, painful and in some settings impossible to do in patients with chronic HCV infection in addition of glutathione s-transferase activity and level of nitric oxide.