الفهرس 
Title pageOnly 14 pages are availabe for public view
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Abstract
PC is the second most common malignancy in males and the fifth most common cause of cancer mortality. Survival rates drops dramatically if distant metastases, especially skeletal, are discovered. New predictive biomarkers must be discovered in order to enhance patient outcomes and clinical care in prostate malignancy patients. Long non-coding RNAs, assume a vital part in the organic and neurotic cycles of numerous malignancies, including cell expansion, relocation, and intrusive in prostate malignancy patients
. SChLAP1 and ATB are long noncoding RNA that shows outlier expression in a several malignancies and may be linked to tumor cell invasion and metastasis.
The goal of this study was to investigate the significance of lncRNA ATB and SChLAP1expression in metastatic human prostate cancer relative to routine investigations including bone scan and PSA levels.
Our results indicated a significant elevation in lncRNA SHLAP1 and ATB expression in bone scan-diagnosed metastatic PC patients. This increase was significantly associated with advanced clinical stage, Gleason sum and tumor size.
ROC curve analysis has demonstrated that lncRNA SCHLAP1 expression in urine samples of PC patients has high specificity (100%) and high-to-moderate sensitivity (68%) at cutoff point of 2.528. LncRNA-ATB expression a high sensitivity (93.75%) and specificity (75.76%) at a cutoff value of 4.55 using bone scan results as a gold standard. When compared to serum PSA at the clinical threshold, Urine lncRNA SCHLAP1 expression showed superior specificity and lncRNA-ATB expression exhibited higher sensitivity for PC metastasis compared to serum PSA at clinical cutoff.
To identify factors that correlate with prognosis using Cox proportional hazards regression model analysis. In univariate analysis, Gleason score >8, tumor size >2, lncRNA ATB express >4.55, lncRNA SCHAP >2.53, and PSA >35 pg/ml were predictive of positive bone scan. Only ATB was significant regardless of the other adjusted factors. Neither SCHLAP1 nor PSA could independently predict a positive bone scan in multivariate analysis. In general, the multivariate analysis showed a decrease in significance levels and in the odds ratios (OR) with the exception of ATB which had an increase in OR.