الفهرس | Only 14 pages are availabe for public view |
Abstract Atopic dermatitis (AD) is a common, chronic, relapsing, inflammatory skin disease that primarily affects young children. It results in significant morbidity and adversely affects the quality of life. Although the cause of AD is not fully understood, AD is a disease that develops as a result of a complex interplay between the innate and adaptive immune responses, environmental factors, and activation of keratinocytes which produce various pro-inflammatory cytokines. Periostin is an extracellular matrix (ECM) protein belonging to the fasciclin family, it binds to other ECMs, collagen I, fibronectin, and tenascin-C, and enhances collagen fibrillogenesis by activating lysyl oxidase, Periostin is reexpressed in adult life after myocardial, vascular and skeletal muscle injury and after bone fracture. Periostin has emerged as a novel mediator in chronic states of allergic diseases and plays an important role in tissue remodeling in allergic inflammation. Periostin has a unique role as an intrinsic mediator in amplifying and maintaining allergic skin inflammation by linking Th2-type inflammation and keratinocyte activation, thus, periostin may be a key molecule in the development of chronicity in AD inflammation. The study was conducted on a total number of 80 subjects; these included 40 patients with AD; childhood phase, beside 40 age and sex matched healthy subjects as a control group. |