الفهرس 
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Abstract
Cancer is a miscellaneous class of diseases with the potential to become malignant through the acquisition of various aberrant characteristics during their development. Cancer is caused by external factors, such as tobacco, infectious organisms, and an unhealthy diet, and internal factors, such as inherited genetic mutations, hormones, and immune conditions. These factors may act together or in sequence to cause cancer. The ascites is referred to neoplastic cells that are proliferated after injection of tumor cells into the peritoneal cavity. Frequently, tumor virulence increases via repetitious passages. Cells gain hetero translatability and converted to the ascites form. A tremendously hopeful approach for cancer prevention nowadays is chemoprevention, even nanotechnology which is welldefined as the usage of synthetic or natural agents (alone or in combination) to block the development of cancer in human beings. Several natural products from plants, vegetables, and herbs have been approved as sources for cancer chemopreventive drug development. Various therapeutic agents are available with a range of actions to fight cancer. These treatments are restricted due to their side effects. Drugs and surgeries available for the treatment of cancer are very expensive and the situation demands the need for alternative medicine. Therefore, this study evaluated the possible curative role of amygdalin and sorafenib co-administration in EAC-bearing mice. In the current study, mice were divided into the following main groups as follows: 1. Gp1: (EAC control group), mice inoculated with tumor cells alone 2. Gp2: (EAC+AMY), mice inoculated with EAC and then treated with amygdalin (300 mg/ kg mouse) daily for 14 days 3. Gp3: (EAC+SOR), mice inoculated with EAC and then treated with sorafenib (30 mg/ kg mouse) daily for 14 days 4. Gp4: (EAC+AMY+SOR), mice inoculated with EAC and then co- treated with amygdaline and sorafenib as in Gp2 and Gp3 daily for 14 days The results obtained from this study can be summarized as follows: Firstly: the biochemical changes and caused by EAC transplantation: 1. A Significant increase in body weight. 2. Tumor volume (volume of Ascitic fluid) in the untreated groups was increased significantly. A marked significant increase in live tumor cell count or dead tumor cell count. 3. A significant increase in liver enzymes, such as the enzyme transporter of alanine acid (ALT), the enzyme transporter of aspartic acid (AST), and glutamyl transferases (GGT), while there was a significant decrease in albumin and total proteins. 4. A significant increase in total lipid profile in all groups. 5. A significant increase in kidney functions in all groups. 6. A significant alteration in hematological profile. 7. A significant increase in levels of oxidative stress markers in the liver, such as malondialdehyde. 8. A significant decrease in the antioxidant system in the liver, such as GST, and CAT. 9. Abnormality levels on the cell cycle of EAC cells. 10. Downregulation of Bax, and Caspase-3 gene expression and upregulation of BCl-2 gene in EAC. Secondly: beneficial effects of administration of AMY and SOR on biochemical and molecular alterations: 1. Perfection in body weight in some groups. 2. Tumor volume (volume of Ascitic fluid) in the treated groups was decreased significantly. A marked significant decrease in live tumor cell count or dead tumor cell count. 3. Improvement in both serum and liver enzyme levels (ALT, AST, and, GGT) and, improved albumin (Alb) and total proteins (TP) concentration. 4. Perfection levels in lipid profile, kidney functions, and hematological profile were observed after treatment with AMY+SOR. 5. Reduced the hepatic levels of oxidative stress markers (MDA) and enhanced the antioxidant parameters (GST, and CAT). 6. Suppression of malignancy and metastases and arrested cell cycle. 7. As well as improvement in the apoptotic markers in comparison to EAC bearing positive control group.