الفهرس 
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Abstract
The present study was carried out in the Clinical Pathology Department, Faculty of Medicine, Minia University Hospital. It was conducted through the period from March 2020 to April 2021. The aim of this study was to measure the level of CXCL-10 and TGF-B1 in chronic HCV patients to determine their role in responsiveness to direct acting antiviral therapy.
The results of this study were summarized as follows:
• There was statistically significant decrease in hemoglobin level, platelet count and Prothrombin concentration in group I and IIb compared to group IIa and III.
• There was statistically significant increase in WBCs count, INR, AST, ALT, DB, TB and PCR level of HCV in group I and IIb compared to group IIa and III.
• There was significant positive correlation between CXCL10 and TGFB1 level in all studied groups.
• There was significant positive correlation between TGFB1 and AST, ALT, PCR level of HCV, AFP, INR, TB and DB. However, there was significant negative correlation between TGFB1 and ALB.
• There was significant positive correlation between CXCL10 and AST, ALT, PCR level of HCV and AFP. However, there was significant negative correlation between CXCL10 and INR.