الفهرس 
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Abstract
Non melanoma skin cancers refer to all types of cancers that
occur in skin that are not melanoma, in which BCC and SCC are the
commonest. Transient receptor potential (TRP) channels are group of
ion channels located mostly on the plasma membrane of numerous
animals and human cells, TRPM8 is the most notable member of the
TRPM subfamily. TRPM8 is aberrantly expressed in several types of
cancer, including lung carcinoma, breast carcinoma, neuroblastoma,
osteosarcoma, neuroendocrine tumor and urothelial carcinoma.
Transient receptor potential. (TRP) channels play an important role in
tumor-related functions including regulation of proliferation,
differentiation, apoptosis, angiogenesis, migration, neurosecretion,
and invasion during cancer progression.
The aim of this study was to investigat the role of TRPM8 in
nonmelanoma skin cancers through its immunohistochemical
localization in skin biopsies of these diseases. Furthermore, evaluate
and compare the immunohistochemical expression of TRPM8 in the
tissues of non melanoma skin tumors from BCC and SCC patients and
normal cutaneous ones from controls. In addition, we aimed to
correlate its expression with different clinicopathologic parameters of
the studied cases.
This study was carried out on 50 patients. They were 15 cases
having BCC and 35 cases having SCC (as group I). In addition, 50
apparently healthy subjects were included as controls ( as group II).
Cases of BCC and SCC were selected from Dermatology Outpatient
Clinic at Menoufia University Hospital during the period from
December 2018 to September 2020. Control subjects were selected from those attending Plastic Surgery Department, Menoufia
University Hospital. All subjects on the study singed a written consent
form, approved by The Committee of Human Rights in Research in
Menoufia University before study initiation.
They were subjected to detailed history taking and
dermatological examination. Biopsies were taken from all cases and
control subjects. Routine histopathological examination with H&E
stain was done as well as immunohistochemical staining to evaluate
the expression of TRPM8 by using Rabbit polyclonal antibodies.