الفهرس 
ThalassemiaOnly 14 pages are availabe for public view
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Abstract
Back ground Beta thalassemia is one of the most hereditary diseases in Egypt.
Over the years, the life expectancy of the patients has been increased significantly.
Aim of work to measure serum Cystatin-C in children with B-thalassemia major
in Fayoum and to compare with Albumin-Creatinine ratio as an indicator of
nephropathy.
Methods We conducted our case-control study on 41patients of beta thalassemia
major on chelation therapy and 41 healthy children. Kidney function was assessed
by serum urea and creatinine which used to calculate eGFR by Schwartz formula,
A/C ratio and serum cystatin C.
Results Among the thalassemic patients themselves, we found that 26.7% had
kidney dysfunction determined by eGFR below 90 mg/min/1.73m 2 . These affected
patients were found to have significant difference between them and other
thalassemic patients regarding duration of chelation therapy (P value:0.002),
frequency of blood transfusion (P value <0.0001), serum urea (P value:0.001) and
creatinine (P value <0.0001), eGFR (P value <0.0001), A/C ratio (P value
<0.0001) and serum cystatin C (P value:0.009).
Conclusion Serum cystatin C might be a good diagnostic test for early detection of
glomerular dysfunction like A/C ratio do.