الفهرس 
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Abstract
Summary
This in-vivo study was performed to evaluate the efficacy of noninvasive
procedures through biomimetic mineralization of a fluoride gel
(Elmex® gelée), bioactive glass materials with and without fluoride
(BioMin™ F) and (BioMin™ C) respectively and self-organizing biomimetic
peptides (Curodont™ D’senz) in the treatment of dentinal hypersensitivity
due to early non-carious cervical lesions.
Twenty-eight patients with an age ranging between (20–45 years) with
self-reported history of dentin hypersensitivity were selected to participate in
the present study. Each patient’s dentition was evaluated sequentially for
evidence of erosion, abrasion or gingival recession (EAR) at facial cervical
region and was examined with an evaporative air-blast stimulus to select at
least one sensitive tooth having a Schiff Sensitivity Score ≥2 and an occlusion
score of 4–5 as determined by scanning electron microscope of replica
impressions of the sensitive area at the screening visit.
Eligible patients were randomly distributed into four treatment groups
of seven patients each. Patients of group I and group IV applied Elmex Gele’e
fluoride gel and CurodontTM D’senz gel respectively, while those of group II
and group III brushed with BioMin™ F and BioMin™ C toothpastes
respectively.
All groups were subjected to a clinical follow up schedule representing
five follow up periods (baseline, after 3, 6, 9 and 12 weeks) during which, the
efficacy of each material in treatment dentin hypersensitivity was assessed in
response to evaporative air-blast sensitivity stimulus utilizing two scales; an
examiner-based Schiff Sensitivity Scale and a subjective utilizing a Visual
Analogue Scale. In addition, objective electrical sensitivity assessment test was performed utilizing digital electrical pulp tester. The extent of tubule
occlusion of hypersensitive areas was examined under the scanning electron
microscope using replica negative impressions of randomly selected patients.
The results of current study revealed that, all the tested groups showed
different degree of dentinal hypersensitivity relieving symptoms with
significant difference in all groups through different assessment periods.
group III recorded a statistically significant highest reduction rate of dentin
hypersensitivity early after 3 weeks of application as assessed by electrical
sensitivity test, SSS and VAS revealing that BioMin™ C provided the earliest
relieving effect.
The effect of all the tested groups on dentin hypersensitivity showed no
statistical significant difference at baseline and 12-week assessment periods
as measured by SSS, VAS and OS. However, there was a statistically
significant difference among the groups at baseline and 3 weeks and a highly
statistically significant difference at 12 weeks based on electrical sensitivity
values. The significant difference was found between group I versus group II
at baseline. In addition, group I versus groups II and III at 3 weeks. While, at
12 weeks, group IV was significant different from group I and group II and
highly significant different from group III.
On the other hand, a statistically significant difference among all tested
groups at 3 ,6 and 9 weeks was found as assessed by VAS. The significant
difference was found between group I and group II versus group III at 3 and 6
weeks indicating that patients treated with BioMin™ C showed significantly
highest pain relief compared to those treated with Elmex Gele’e and BioMin™
F at such assessment periods.