الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Obesity is a life-threatening illness caused by accumulation of excess fat. Obesity has a complex etiology that involves genetic, physiological, environmental, psychological, social, and economic components. Cardiovascular illness, pulmonary disease, hypertension, type 2 diabetes, and cancer are among medical problems of obesity.
Obesity is caused by a combination of genetic and environmental factors. Obesity and visceral fat deposition, as well as an increased risk of impaired glucose tolerance, T2 DM, and high blood pressure, have all been linked to higher circulating IL-6 levels. By managing the acute phase response and altering glucose and liver metabolism, IL-6 can be anti-inflammatory, regenerative, and homeostatic.
Many populations have been studied to see if IL-6 polymorphisms are linked to chronic illnesses. The rs1800796 polymorphism may influence the IL-6 gene’s transcriptional effectiveness.
In our study that was conducted on 100 subjects: 35 patients of simple obesity, 35 patients of complicated obesity, and 30 healthy subjects. All subjects did lab investigations including: IL-6 gene snp rs1800796 polymorphism using taqman realtime pcr assay technique, cbc, urea, creatinine, sgot, sgpt, serum albumin, total serum bilirubin, fasting blood sugar, HbA1c, uric acid, amylase, lipase, crp, lipid profile, tsh, ft4, and they all did u/s abdomen.
In patients with simple obesity, and patients with complicated obesity, 68.6% and 74.3% respectively had the homozygous allele (GG) for IL-6 gene snp rs1800796 polymorphism, while for the healthy subjects 63.3 % had the heterozygous allele (CG).
Regarding the u/s abdomen 54.3% of patients with simple obesity had fatty liver only, 8.6% had both fatty liver and pancreas. For patients with complicated obesity 74.2 % had fatty liver only, and 11.2% had both fatty liver and pancreas. In healthy subjects, 86.7% had neither fatty liver nor pancreas, and 13.3% had fatty liver only.
In the univariate