الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Annually, hundreds of CO poisoning related deaths occur, especially in the autumn and winter seasons. In Egypt, the situation is not different from worldwide and CO poisoning still represent a major health problem and causes many morbidities and mortalities.
The most usable diagnostic test obtainable in a suspected CO poisoning is a CO-Hb level. Although high CO-Hb levels confirm exposure to CO, particular levels are not necessarily predictive of symptoms or outcome.
The use of advanced ECG analysis for anticipating sudden death and dysrhythmias has grown in popularity. Although preliminary investigations are hopeful, the use of advanced ECG analysis in clinical toxicology has yet to be thoroughly established.
Recent studies support the idea of using new biochemical indicators such as B-type natriuretic peptide (BNP) in the diagnosis of cardiac toxicity. However, there are few studies in literature describing the relation between plasma BNP levels and cardiac toxicity in acute CO poisoning.
The present study aimed to document electrocardiogram (ECG) changes and assess their prognostic value in patients with acute carbon monoxide poisoning. Moreover, the current study aimed at measuring the serum levels of n-terminal pro- brain natriuretic peptide (NT PRO-BNP) and Troponin as well as evaluating their efficacy as a prognostic tool in predicting severity and outcome in patients acutely poisoned with carbon monoxide.
The current work was conducted on 71 subjects divided into two groups. The case group which included 50 carbon monoxide acutely poisoned patients presented to Alexandria Poison Center (APC), Alexandria Main University Hospital, Alexandria, Egypt. Twenty-one healthy subjects were also included in the study as a control group. An informed consent was obtained from all participants before starting the study.