الفهرس 
LICHEN PLANUSOnly 14 pages are availabe for public view
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Abstract
Lichen planus is a common, chronic, inflammatory, pruritic disorder involving the skin, mucous membranes, nails and hair follicles. Systemic corticosteroids are considered the treatment of choice for generalized LP. However, the use of corticosteroids is limited due to multiple side effects. Oral mini pulse therapy represents good alternative. Also, Methotrexate can be used as alternative and safe modality in LP. The aim of this study was to compare the efficacy and safety of oral methotrexate therapy versus OMP betamethasone therapy in treatment of different types of lichen planus. The current study was carried out on 40 patients presenting with lichen planus. Patients were selected from those attending the outpatient clinic of Dermatology and Venereology Department, Tanta university hospitals from January 2019 to January 2020 with approval of the medical research ethical committee to the Tanta faculty of Medicine. We evaluated the safety and efficacy of oral methotrexate 7.5 mg weekly and OMP betamethasone 3 mg weekly in the treatment of different types of lichen planus. A total number of 40 patients who diagnosed clinically to have lichen planus were enrolled in the study. Patients were divided into two equal groups. Each group included 20 patients (group A for oral methotrexate and group B for OMP betamethasone). Both groups were almost matched in the demographic data, associated medical conditions, type of lichen planus lesions and severity of extension of lesions in order to eliminate any confounding factor which could affect efficacy of treatment or development of side effects.