الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy worldwide. The multi-drug resistance 1 (MDR1) gene encodes a 170-kDa membrane transport protein called P-glycoprotein. The physiological expression of P-glycoprotein (P-gp) in tissues is one of the determinants for drug detoxification in various cells and thus provides a cellular defense mechanism against potentially harmful compounds. Moreover; elevated production of P-gp can result in the increased efflux of the cytotoxic drugs from the cancer cells, thus; lowering their intracellular concentrations.
Polymorphism of C3435T in exon 26 and C1236T in exon 12 of the MDR1 gene has a significant correlation with the P-gp expression level.
The aim of this study was to examine the MDR1 C3435T and MDR1 C1236T Polymorphisms in ALL patients and its relation to disease prognosis and response to treatment.
The current study was conducted on 60 subjects in El Shatby university children’s hospital. All subjects were divided into two groups; group I (patient group) involved 30 newly diagnosed patients with childhood ALL, and group II (control group) involved 30 healthy, age, and sex-matched control. After the approval of the medical ethics committee, the study was done, and informed consent was taken from the patients.
In the current study, there was no statistically significant difference regarding the genotype distribution of C3435T polymorphism of the MDR1 gene and the allele frequencies between the patients and control groups. There was no statistically significant difference between 3 types of genotypes of MDR1 C3435T p