الفهرس | Only 14 pages are availabe for public view |
Abstract Non-alcoholic fatty liver disease (NAFLD) is a major public health issue due to its high prevalence worldwide and potentially serious sequelae. Nonalcoholic fatty liver disease (NAFLD) is characterized by the presence of extra fat in the liver, exceeding 5–10% of liver weight. Most patients with NAFLD have increased liver fat only (simple steatosis). Some of the patients develop hepatic inflammation, a condition known as nonalcoholic steatohepatitis (NASH), and up to 20% of patients experience progressive hepatic fibrosis and may eventually progress to liver cirrhosis or failure and even hepatocellular carcinoma. The gold standard for NASH diagnosis is liver biopsy. This procedure, however, is invasive, overpriced, and associated with rare but potentially risky complications and sampling errors; hence, it is not appropriate as a screening tool. One of the imaging techniques which are used as noninvasive diagnostic test for NAFLD is ultrasonography, by which the incidence and severity of fatty liver are measured by grading of fatty liver (Grade 1, 2 and 3) according to the hyperechogenicity of the liver tissue, the divergence between liver and diaphragm and the visibility of vascular structures. The aim of the study is to evaluate circulating selenoprotein P (SEPP) levels in patients with nonalcoholic fatty liver compared with healthy controls. This is a retrospective study that was conducted on 72 patients (60 males and 12 females) with NAFLD (cases), and 36 healthy volunteers (25 males and 11 females) without NAFLD or any chronic liver disease as controls cross matched with patients in age and sex in the period between April 2019 to March 2020. The mean ± SD ages of patients and controls were (48.38 ± 7.24) years and (46.11±6.72) years respectively. All subjects (cases and controls) had been collected from outpatient clinics of the GI department of Menoufia university hospitals and the controls are members of staff of the hospital. The main results of the study revealed that: There was no significant difference between groups regarding age nor gender. There was significant difference between groups regarding BMI and Waist circumference. There was significant difference between groups regarding liver function tests. There was no significant difference between groups regarding Urea but there was significant difference between groups regarding creatinine. There was significant difference between groups regarding Glucose, Insulin and HOMA-IR. There was highly statistical significant difference between groups regarding to serum Serum selenoprotein P. There was positive correlation between SEPP levels and both creatinine and Log (GGT), and negative correlation between SEPP levels and (glucose, insulin, (HOMA-IR) and BMI). In conclusion, Selenoprotien p concentrations were decreased in subjects with NAFLD than normal healthy subjects. Finally, we recommend for further studies on large geographical scale and on larger sample size to emphasize our conclusion. |