الفهرس 
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Abstract
Protective Effect of Febuxostat on Lincomycin-Induced Hepatotoxicity and Nephrotoxicity in Rats, the study was to investigate the ameliorating and protective effect of febuxostat on the expected adverse effects of lincomycin on the liver and kidney. Twenty- four albino rats were used. The albino rats were divided into 4 groups as following : ((G1) Control, (G2) given lincomycin (500 mg/kg), (G3) given febuxostat (10 mg/kg), (G4) given lincomycin (500 mg/kg) plus febuxostat (10 mg/kg)) orally by stomach tube for 10 successive days. Blood samples and samples of the liver, kidneys and skeletal muscles were collected for hematological, biochemical and histopathological examination. Lincomycin treatment caused several adverse effects on the blood, biochemical parameters, impaired liver and kidney function causing pathological changes in the tissues in the liver, kidneys and skeletal muscles of treated rats. The results obtained this study showed that febuxostat has strong protective effects against lincomycin- induced hepatotoxicity and nephrotoxicity in rats.