الفهرس 
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Abstract
Hyperlipidemia constitutes a major problem causing serious health problems. The
current study was conducted to investigate the effect of Pomegranate (PC) and Licorice
(LC) extracts as anti-hyperlipidemic agents in rats.
Methods:
Sixty male Wister rats were used in current study. They were divided into 6 groups;
group Ι: Control (C), group ΙΙ: Pomegranate control (PC), group ΙΙΙ: Licorice
Control (LC), group ΙѴ: Hyperlipidemia control (H), group Ѵ: Hyperlipidemia
pomegranate (HP), group ѴΙ: Hyperlipidemia licorice (HL).
Pomegranate was administrated at a dose 200 mg/kg body weight, while licorice was
administrated at a dose 400 mg/kg body weight. All doses were given by oral gavage.
The following parameters were measured:
1-Body weight and relative organs weight
2- Hematological parameters: RBCs, Hb, HCT, MCV, MCH, MCHC, WBCs,
Neutrophil, Lymphocyte and Monocyte counts.
3- Biochemical parameters: lipid profile (total cholesterol (TC), triglyceride (TG), high
density lipoprotein (HDL-C), low density lipoprotein (LDL-C), very low-density
lipoprotein (VLDL-C), glucose, liver enzymes (ALT, AST), albumin, globulin, A/G,
total protein (TP), Kidney functions (creatinine and uric acid).
4- Lipid peroxidation and antioxidants (GSH, MDA and SOD).
5- Immunoglobulin (IgM and IgG)
6- Cytokines (TNF-ɑ and IFn_γ)
Results:
The results showed that pomegranate peel and licorice extracts were significantly
reversed the levels of serum lipid profile, glucose, hepatic and renal damage markers,
antioxidant, cytokines (TNF-α and IFn_γ) and immunoglobulins (IgM and IgG) of
hyperlipidemic rats. Histopathological examination of liver and kidney tissues was in
concurrence with the biochemical results.
Conclusions:
It is logi
cal to consider that the antihyperlipidemic and antioxidative properties of pomegranate
and licorice are mechanistically achieved. So, pomegranate and licorice could be used
as protective agents against hyperlipidemia and subsequent resulted metabolic
disorders.