الفهرس 
Ethylenediaminetetraacetic acid (EDTA) and its applications
2.8. Effect of EDTA and its derivatives on body weight and organ weightOnly 14 pages are availabe for public view
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Abstract
Recently, there is a sharp increase in industrial, agriculture, and medical applications; several food additives were used in these applications. Thus, more attention was focused on the embryological, histopathological, molecular, and biochemical effects of these food additives induced by supplementation of the famous food additives to rats. However, to our knowledge the research on the embryological and molecular effects of the food additives very limited.
CaNa2EDTA is used in cosmetics, personal care products, medicine, and aquaculture fields. It considered as the most common food additives. CaNa2EDTA is not metabolized by the human body, and it is rapidly excreted in the urine. EDTA is eliminated from the body, 95% via the kidneys and 5% by the bile and did not pass into erythrocytes and transferred slowly into the spinal fluid compartment. EDTA and its derivatives do not permeate the cellular membrane to a significant extent; thus, most of the EDTA remains in the extracellular fluid until excreted in the urine.
To our knowledge, no available literatures on the chronic toxicity of CaNa2EDTA on the male and female rats before mating and on their offspring before mating. The present study aimed to evaluate the effect of CaNa2EDTA on embryological toxicity, histopathological changes, expression of gene coding for ribosomal m-RNA in tissues of embryos, growth rate, haematological factors, and the biochemical factors in rats and their offspring.