الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Sulfasalazine is a medication that is often used to treat rheumatoid arthritis and inflammatory bowel disease. 5-aminosalicylic acid and sulfapyridine make up sulfasalazine. The active chemical responsible for the drug’s therapeutic success in ulcerative colitis is 5-aminosalicylic acid (mesalazine), with the sulphapyridine component (working simply as a carrier for 5-aminosalicylic acid) obviously being responsible for the bulk of side effects.
Renal damage caused by sulfasalazine could be permanent. This includes glomerulonephritis and acute renal failure. Until today, there is no particular cure for kidney insults induced by sulfasala¬zine.
Because oxidative stress is thought to be the main mechanism of toxicity induced by sulfasalazine, utilizing antioxidants may help to mitigate the drug’s potentially harmful effects.
Garlic (Allium sativum) is a Lilliaceae bulb-forming herb. It is the world’s oldest cultivated plant, with over 4000 years of use as a food, spice, and folkloric medicine. The antioxidant level of aged garlic extract is significant, and it possesses health-protective properties. Garlic has considerable disease-prevention effects in the areas of cardiovascular disease and cancer.
The present work had two aims: to evaluate the histological and histochemical changes induced by sulfasalazine on the proximal and distal tubules of adult male albino rats. Second, to investigate the possible protective role of garlic oil depending on its antioxidant property.