الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Chronic kidney disease (CKD) is a worldwide problem, with a disproportionately high burden in underdeveloped countries due to limited resources. Malnutrition plays a critical role in the development of growth failure in children with CKD, and it is recognized as a key player in this patient population’s development of growth failure. The present study was performed to evaluate serum levels of ghrelin and examined potential correlations between ghrelin ,hs-CRP and malnutrition in CKD with end-stage (V). Thus, it is important to identify potential eliciting factors of the development and progression of CKD. The current study was conducted on 50 CKD patients stage V. The patients were divided according to their hemodialysis into two groups: The first one consists of 25 children, not on hemodialysis with ages from 4 to 17 years. The second group consists of 25 children on regular hemodialysis with ages from 4.5 to 17 years. Results : Children on regular hemodialysis were significantly older than those with no hemodialysis. Gender did not differ significantly between both groups. Children on regular hemodialysis were significantly associated with comorbidities when compared to those, not on hemodialysis. Type of comorbidities did not differ significantly between both groups. By comparing those on hemodialysis and those not on hemodialysis, no significant differences were found between both groups regarding anthropometric measures. By applying global score, both studied groups had mild to moderate malnutrition (80% for each) and severe malnutrition in 20% for each. Nutritional status estimation found that majority of the CKD patients was mild to moderately malnourished in our study. Assessment of nutritional markers have been performed in our study. Patients on regular hemodialysis were significantly associated with higher iron, ferritin, PTH, creatinine, K, highly sensitive-CRP, lower platelet count, e GFR, and Na when compared to those not on hemodialysis. Also, there was no significant difference between patients with CKD on hemodialysis and not on hemodialysis groups regarding serum albumin. Conclusion : There is no relationship between ghrelin level and hs- CRP in all CKD patients. hs-CRP was positively correlated with BMI. This implied that there may be a pathophysiological interaction between excess weight, inflammation, and CKD in patients with end stage. No significant correlations were found regarding hs-CRP versus other studied parameters.