الفهرس 
Breast cancer
Arrestins genesOnly 14 pages are availabe for public view
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Abstract
Arrestins are a family of intracellular proteins that includes two
visual arrestins (Arrestin 1 and Arrestin 4) and two non-visual arrestins,
defined as Arrestin 3 (or β-Arr1) and Arrestin 2 (or β-Arr3). Both β-
Arr1& β-Arr2 genes are widely expressed in most types of mammalian
cells. They are known with their regulatory role in G protein coupled
receptors (GPCRs) desensitization. Thus, decrease their working
activities could induce signal termination. Liganded (signal stimulated)
GPCRs are internalized through a mechanism involving arrestindependent
binding to clathrin-coated pits. This clathrin mediated
endocytosis (CME) is the most common endocytic mechanism, used in
receptor internalization and involves a subset of regulatory and
scaffolding proteins including clathrin, β-arrestins, dynamine and some
adaptor proteins (called Adaptins). Subsequent studies have introduced β-
Arrs as a part of the multi-protein complex (receptorsome) involved in
targeting receptor kinase complex to clathrin-coated pits followed by
receptor internalization. Moreover, β-Arrs mediates other pathways
distinct from the G protein-dependent activation.