الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Acne is one of the most common skin disorders. It is estimated to affect 9.4% of the world population making it the eighth-most prevalent disease worldwide. The disease is not life-threatening, though it affects the quality of life, self-esteem, and mood, and increases the risk of anxiety, depression. The presence of acne is a significant cause of morbidity, as a result of the cosmetically unappealing lesions on the face, chest, shoulders, and back.
Sebum is the secretory product of sebocytes derived from sebaceous glands. Exaggerated sebocyte activity under the effect of increased insulin-like growth factor 1 (IGF1) and androgen signaling results in the production of sebum with higher amounts of monosaturated pro-inflammatory lipids.
Several drugs are used in the treatment of acne vulgaris, Isotretinoin
(13-cis-retinoic acid) is the most effective sebum suppressive drug, which is considered the first choice for the treatment of cystic acne.
Isotretinoin since its approval remains the most effective treatment for severe cases of acne and has the best impact on the quality of life. Treatment with isotretinoin (13-cis-retinoic acid) results in dramatic SG shrinkage and reduced sebum production.
Many authors had suggested that sebocyte apoptosis is the key mode of action of systemic isotretinoin in different ways. This apoptosis was hypothesized to be due to increased p53 expression