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العنوان
High dose versus low dose oxytocin for augmentation of delayed labour in obese women:
A randomized clinical trial /
المؤلف
Mostafa, Esraa Gamal Abdelnaser,
هيئة الاعداد
باحث / اسراء جمال عبدالناصر
مشرف / احمد محمد عباس
مناقش / عمر ممدوح شعبان
مناقش / صفوت عبدالراضى
الموضوع
oxytocin for augmentation.
تاريخ النشر
2022.
عدد الصفحات
98 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض النساء والتوليد
الناشر
تاريخ الإجازة
19/4/2022
مكان الإجازة
جامعة أسيوط - كلية الطب - Obstetrics and gynecology Department
الفهرس
Only 14 pages are availabe for public view

from 98

from 98

Abstract

For augmentation of delayed labor, high- or low-dose oxytocin can be used, but the evidence for promoting high-dose in obese women is weak. In obese women, labor progress is often delayed, leading to a caesarean section despite labor augmentation with synthetic oxytocin The study aims to determine the effect on caesarean section rate of high-dose versus low-dose oxytocin for augmentation of delayed labour, scheduled vaginal or cesarean delivery rates, maternal and fetal outcomes in term pregnancies. in obese women We included 202 patients were randomly assigned to two groups in a randomized controlled trial (RCT) study. Patients were divided into two groups: group I (low dose oxytocin) were given 2 mU/min of oxytocin, which was gradually increased by 2 mU/min every 30 minutes until adequate uterine contractions were achieved. Patients in group II (high dose oxytocin) were given 4 mU/min of oxytocin, which was gradually increased by 4 mU/min every 30 minutes until adequate uterine contractions were achieved202 women were included in (high-dose n = 99; low-dose n = 103). Both management were equally effective in clinical data with no significant difference between the two studied groups (P>0.05). Duration of active phase (hours), were significantly increase in low dose oxytocin group than in high dose oxytocin group (p=0.011).The duration of 2nd stage (min.) was significantly lower in low dose oxytocin group to high dose oxytocin group (10.48 ± 3.04 min. vs 9.64 ± 2.54 min.; p=0.027). Oxytocin dose and duration of oxytocin between the two groups was statistically significant. The rates of Caesarean section did not differ between groups
(8.7% and 8.1%); more uterine tachystole (34.0 percent versus 50.5 percent); similar rates of instrumental vaginal births. In terms of neonatal outcomes, there were no differences Except for reducing labor duration, high dose oxytocin had no advantages over low dose oxytocin in labor augmentation. Low-dose oxytocin is less likely to cause uterine hyperstimulation, making it a safer option. To avoid unnecessary hyperstimulation and fetal distress, a low-dose oxytocin regimen is recommended. More research is needed to back up our findings.