الفهرس 
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Abstract
Lymphomas represent a heterogeneous group of lymphoid malignancies with varied patterns of clinical behavior and responses to treatment. The prognosis depends on the histologic type, clinical factors, and, more recently, molecular characteristics. Lymphomas are classified according to a system established by the World Health Organization (WHO), with the most recent fourth edition published in 2008 (7). The WHO classification distinguishes lymphoid neoplasms derived from precursor lymphoid cells from those derived from mature lymphoid cells and further separates each group into neoplasms of B-cell or T-cell origin(7). There are two main forms of lymphoma including Hodgkin‘s lymphoma and non-Hodgkin‘s lymphoma (NHL), and among NHL, nodal and extranodal NHL are differentiated. The skin is the second most common site of involvement in extranodal NHL, after the gastrointestinal tract, with an overall incidence of approximately 1:100 000(8). In this study we studied the prevalence of cutaneous T and B cell lymphomas in Gharbia Governorate in the mid delta of Egypt. This study was based on the record study, data collected from registry unit at Tanta Cancer Center and outpatients Clinic of Department of dermatology and venereology (Tanta University Hospitals). It was found that there were 311 patients diagnosed as having cutaneous T and B cell lymphomas during the period from 1999 to 2019. Statistical analysis was done and the result showed the following : • Regarding analysis of data of cutaneous T and B cell lymphomas patients : - Cutaneous T cell lymphomas were more common (accounting for 82.9% of the patients) than cutaneous B cell lymphomas (21.3% of the patients). - -There was no sex predilection as the female to male ratio was 1.1:1. - -Most of cases were elderly patients above 50 years old. The highest incidence was at age group above 80 years old awhile the least incidence rate in the age group (10-20 years old) . - There was a significant association between age and occurrence of T and B cell lymphoma - It showed that the highest incidence rate was recorded in 2012 and the least incidence rate was recorded in 2005. There was insignificant association between time and occurrence of T & B cell lymphoma. - It was found that the highest incidence rate (121.6 p/m populaion) was recorded in Tanta and the least incidence rate (25.92 p/m population) was recorded in Zefta. There was significant association between district and occurrence of T & B cell lymphoma. - Cutaneous T and B cell lymphomas registered patients (311 patients) represent 0.55% of total cancer count (56176 patients). - Cutaneous T and B cell lymphomas registered patients (311 patients) represent 32.6% of total skin cancer count (953 patients). - Cutaneous T and B cell lymphomas registered patients (311 patients) represent 46.4 % of total non-melanoma skin cancer count (670 patients). - Cutaneous T and B cell lymphomas registered patients (311 patients) represent 109 % of total melanoma skin cancer count (283 patients). • Regarding analysis of data of cutaneous T cell lymphomas patients : - Cutaneous T cell lymphoma was the most common cutaneous lymphoma as it accounted for 82.9 % of the total number of registered patients. - There was no statistical significance in the distribution of cutaneous T cell lymphomas between female and male (ratio 1.15: 1). - It was found that the highest incidence rate was recorded in the age group above 80 and the least incidence rate was recorded in the age group 10-20 years old. There was significant association between age and occurrence of T cell lymphoma. - It showed that the highest incidence rate was recorded in 2012, and the least incidence rate was recorded in 2005. There was significant association between time and occurrence of T cell lymphoma. - It was found that the highest incidence rate was recorded in Tanta followed by the least incidence rate was recorded in El Mahalla Elkobra. There was significant association between district and occurrence of T cell lymphoma. - Cutaneous T cell lymphomas registered patients (258 patients) represent 0.46 % of total cancer count (56176 patients). - Cutaneous T cell lymphomas registered patients (258 patients) represent 27.1 % of total skin cancer count (953 patients). - Cutaneous T cell lymphomas registered patients (258 patients) represent 38.5 % of total non-melanoma skin cancer count (670 patients). - Cutaneous T cell lymphomas registered patients (258 patients) represent 91.1 % of total melanoma skin cancer count (283 patients).• Regarding analysis of data of cutaneous B cell lymphomas patients : - Cutaneous B cell lymphoma were less than cutaneous t cell lymphoma as it account for 17.2 % of the patients. - There was no statistical significance in the distribution of cutaneous B cell lymphomas between males and females as male to female ratio was (1.4:1). - It was found that the highest incidence rate was recorded in the age group above 80 and the least incidence rate was recorded in the age group 10-20 years old. There was significant association between age and occurrence of B cell lymphoma. - It showed that the highest incidence rate was recorded in 2006 and the least incidence rate was recorded in 2014. There was insignificant association between time and occurrence of B cell lymphoma - It was found that the highest incidence rate was recorded in Kafr El Zayat and the least incidence rate was recorded in Zefta. There was insignificant association between district and occurrence of B cell lymphoma. - Cutaneous B cell lymphomas registered patients (53 patients) represent 0.094 % of total cancer count (56176 patients). - Cutaneous B cell lymphomas registered patients (53 patients) represent 5.6 % of total skin cancer count (953 patients). - Cutaneous B cell lymphomas registered patients (53 patients) represent 7.9 % of total non-melanoma skin cancer count (670 patients). - Cutaneous B cell lymphomas registered patients (53 patients) represent 18.7 % of total melanoma skin cancer count (283 patients). - The higher incidence of lymphomas in old age may be reflected to diminished immune survival, DNA damage and more exposure to chronic diseases. - The difference in distribution of cutaneous lymphoma in Gharbia districts may be attributed to the difference in population number which is more in the capital city. Also exposure to risk factors more in the capital city with higher incidence rate of these malignancies. - The difference in the incidence rate of cutaneous T and B cell lymphomas during the studied years may be explained by increase in the population number which leads to decrease in the number of patients per population. Also improvement in diagnostic tools, medical service, and public awareness about the risk factors has been suggested to decrease the number of patients at risk.