الفهرس 
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Abstract
Summary
Primary open angle glaucoma (POAG) is a progressive chronic visual neuropathy caused by retinal ganglion cell death (RGC). Assessment of the neuroretinal rim area, the RNFL and the GCC thicknesses on OCT is utilised as a clinical surgical procedure for estimating the degree of POAG RGC loss. OCT Angiography (OCTA) is a noninvasive imaging method that evaluates the density of blood vessels on the optic disc and macula by very accurate and reproducible measurement of red blood cell movements.
The study was a transverse non-interventional investigation carried out in the Beni-Suef University Hospital department of ophthalmology and comprised 30 POAG patients. The preponderance of POAG patients under study were male (70%) with 42 to 55 years of age and average 47.9 years of age. In the current investigation, the peripapillary and macular microvascular characteristics between OCT-A angiographic and RNFL thickness POAG patients were investigated and compared.
Optical disc RNFL thickness (84.47 in the superior aspect, 83.2 in the lower aspect) and (73.8 in the nasal aspect) were seen in the studies patients assessed by OCT and (63.8 in temporal aspect). Mean vascularity was assessed and found to be (41.5 in the superior aspect), ( 40.47 in the lower aspect) (40 in the nasal aspect) in various directions (41 in the nasal aspect) and (45.3 in temporal aspect).
There are statistically significant positive correlations in the superior, the lower and the nasal aspects between RNFL spacing (by OCT) and vase (by OCT angiography), while there is no significant, positive correlation in the temporal aspect between RNFL (by OCT) and vascular spacing (by OCT angiography). No significant association was found between vascularity in any direction or IOP in the present research.
Compared to RNFL modifications, substantial decreases in the vascular density might deduce a more major role in POAG. Finally, OCT-A identifies the decline in vessel density in the eyes of POAG patients. The reduced vascular density of the POAG eyes means that quantitative OCT-A measures indicate damage to pathophysiologically important tissues of glaucoma. The detection of reduced vessel density in POAG perimetrically shows that OCT-A can identify a significant risk of microvascular alterations in the eyes before visual area impairment is detected.
The present study was hampered by its cross-sectional design, it is unable to determine the difference between the effects of anti-glaucoma medication, depending upon glaucoma medicine and various phases of the POAG.