الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Pregnancy-related hypertension disorders are one of the primary causes of maternal and perinatal morbidity and mortality worldwide. It has been estimated that PET complicates 2-8% of pregnancies globally.
The diagnosis of preeclampsia is characterized by the new onset of high blood pressure plus persistent proteinuria developing after 20th week of pregnancy in a previously healthy women and can be subdivided into non severe and severe PE which present by multi-system damage regardless of proteinuria.
Due to the mortality and morbidity attributed to PET, ongoing researches are recommended for early diagnosis, severity assessment, prevention, and treatment of PET to provide better care for pregnant female and better neonatal outcome.
T cells mature in the thymus, and express either Cluster of differentiation 8 glycoprotein (CD8+ T cells [cytotoxic]) or Cluster of differentiation 4 glycoprotein (CD4 + T cells [helper T cells]). Both of which are used to determine how strong an individual’s immune system is..
This work was designed to evaluate CD4/CD8 ratio as a predictor of preeclampsia severity using body’s immune response as a guide in pursuit to emphasize the immunological theory in pathogenesis of PET. The patients were chosen from antenatal clinic at El-Shatby Maternity University Hospital. We compared 35 Egyptian women with mild preeclampsia with another 35 women who are normotensive during third trimester of pregnancy for CD4%, CD8% and CD4/CD8 ratio.
Statistical analysis results observed that there was statistically significant rise in CD4/CD8 ratio ( shown as increases in CD4% and decrease in CD8%) in patients diagnosed with mild PE over that in healthy pregnant women.
We recommend introducing CD4/CD8 ratio as a routine test for detecting the severity of preeclampsia in pursuit for close follow up and better antenatal care for these women at risk to avoid the catastrophic sequel of