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Abstract Preterm prelabor rupture of membranes (PPROM)is responsible for approximately one third of preterm deliveries.Microbial invasion of the amniotic cavity has been found in approximately 30% of PPROM. The presence of microorganisms in the amniotic fluid (AF) triggers a cascade of inflammatory processes, followed by the infiltration of neutrophils in the fetal membrane, the placenta and umbilical cord. This condition, which is known as histologic chorioamnionitis (HCA), has 2 parts, according to the type of host inflammatory response. It is maternal when the amnion, the chorion decidua and the chorionic plate are affected, and it is fetal(funisitis)when the umbilical cord is involved. Although both HCA and especially funisitis are associated with a higher rate of perinatal mortality and short‐ and long‐term neonatal morbidity, many cases remain clinically silent |