الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Anogenital warts caused by HPV infection do not exhibit a propensity for malignant transformation but cause great psychosocial morbidity. Infection with HPV probably occurs as a result of exposure of the basal cells to virus particles after minor trauma to the epithelium, probably occurring during sexual intercourse.
Cell-mediated immunity (CMI) plays a significant role in wart regression.
CD4 T helper cell have very important role in the fighting of HPV infection. T-cell work as in charge of the progressing of lifelong immunity anti viruses.
This clinical study was conducted to evaluate the level of soluble serum cd4 in 49 patients with external ano-genital warts before and after intra-lesional purified protein derivative injection.
The patients with the clinical diagnosis of multiple warts received an intra dermal injection of 0.2 ml of tuberculin PPD (containing 10, Serum Soluble CD4 level was determined by Enzyme Linked Immune-Sorbent Assay (ELISA) before and after treatment.
The main results of the study revealed that:
The mean age of our patients was 30.59 ± 8.34 years (range from 18 to 55 years). The duration of lesions among the enrolled patients ranged from 1 months to 16 months with a mean of 7.73 ± 4.07 months. The majority of lesions were located on shaft of the penis in 27 patients (55%).
The number of treatment sessions, patient ranged from three to six with a mean of 5.47 ± 0.92 treatment sessions.
Patients with warts achieved complete response in 53%, followed by 32.7% had partial response, and then 14.3% had minimal response.