الفهرس 
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Abstract
Severe sepsis and septic shock cause 30% to 50% of all deaths in intensive care units (ICUs). It’s associated with high cost, prolonged hospital stay and high mortalities. So the need for rapid diagnosis and treatment is critical.
Symptoms and signs are nonspecific for diagnosis of sepsis and these could occur with SIRS and any infections as localized or generalized. Blood culture is the gold standard method yet it takes long time and it has poor sensitivity 30-50% so many cases will be missed and any further delay in administration of antibiotic will increase mortality rates. Serum markers as ESR, TLC and CRP are nonspecific and could be affected by other factors as bone marrow suppression or liver disease.
Macrophages play a key role in sepsis and monocyte& macrophage-derived serum markers are promising markers in diagnosis of sepsis.
sMR is elevated early in sepsis and its level could be correlated with the prognosis of cases. So it was a good candidate for the present study to assess its role in diagnosis of sepsis in ICU patients.
This study was done at Ain Shams University hospital ICUs at the period from October 2019 to November 2020. After confirming cases of sepsis by positive blood culture, sMR levels were assessed by ELISA and the mean was calculated.
There was significant elevation of sMR median values in cases {5 (2 - 10)} compared to the healthy control {0.4 (0.25 - 0.6)} with cut off level of ≥0.7ng/l and AUC was 1.000.
In conclusion, sMR is a promising biomarker which could be used in diagnosis and assessment of prognosis of Sepsis with high sensitivity and specificity.
This aids in rapid detection of cases of Sepsis before further deterioration giving us the chance for rapid administration of antibiotics for indicated cases. This will lead to significant decrease in both rates of infection with multidrug resistant organisms and mortalities in ICUs.