الفهرس 
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Abstract
The aim of the present study to evaluate the clinical effect of Selfassembling
peptides and Amorphous calcium phosphate varnish on the
treatment of post orthodontic enamel white spot lesions WSLs
After the approval of Ethical Committee of the Faculty of Dentistry
Suez Canal University this study was carried on forty teeth of patients
’age range of 16 -25 years. The patients were recruited from a pool of
treated orthodontic patients at Department of Orthodontics, Faculty of
Dentistry, Suez Canal University.
A total of 40 (10 per group) patients teeth were enrolled in this
prospective single-blinded randomized clinical study categorized into
four groups; Control group where patients were instructed for only proper
oral hygiene. Two different remineralizing analogues were used for the
treatment of the post orthodontic white spot lesions WSLs; Selfassembling
peptide P11-4 (Curodont ™ Repair /Regenamel®) and
Amorphous Calcium Phosphate varnish (Enamel Pro® Varnish 5%
Sodium Fluoride Premier Dental). The two analogues were used combine
to form the forth group; through combining self-assembling peptide with
a copious source of calcium phosphate and fluoride ions, that might
introduce favorable results, rather than using them solitary
The Visual clinical examination was carried out under standard
light conditions on the dental chair. ICDASII assessment criteria (0-2)
considered in the study, as we deal with non-cavitated lesions on enamel
surface.
Enamel white spot lesions (WSLs) were evaluated qualitatively
using Vita Easy® Shade spectrophotometer (Vita Zahnfabrik, Germany),
and Quantitavly using Diagnodent® ( KaVo Dental Corporation, USA).
Summary
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The evaluation of WSLs was be done quantitavely using Easy
Shade spectrophotometer to calculate (ΔE) of shade changes, and
quantitatively Diagnodent to calculate (ΔF) the change in fluorescence,
immediately after de-bonding of the orthodontic brackets.
Further follow ups were done to detect the efficacy of the various
re-mineralizing agents on the remineralization of WSLs after one, three,
and six months.
The result of the current study study revealed a quantitative and
qualitative increase in remineralization of post orthodontic WSLs in all
the groups and over time intervals.
However, the WSLs recovery was significantly better in the
combination group followed by the self-assembling peptide group, than
control group which showed the least values of remineralization