الفهرس 
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Abstract
”The present study aimed to identify carriers in close relatives of known patients with beta thalassemia in rural areas of Dakahlia governorate. Our study is one of the objectives of the national project funded by Science and Technology Development Fund (STDF).The study design was cross sectional observational study, conducted on 168 close relatives of known patients with beta thalassemia in rural areas of Dakahlia governorate.Our Inclusion criteria included close relatives of beta thalassemia patients in rural areas of Dakahlia government and excluding cases with other hemolytic anemia and alpha thalassemia. For all subjects clinical evaluation was done including: detailed history taking, complete Physical examination and laboratory investigation for IDA diagnosis and for B- thalassemia carrier detection.The study has been approved by the ethical Committee of Mansoura University, Faculty of Medicine.The current study detected 51/168 (30.4%) β thalassemia carriers of close relatives of β thalassemia major children, detected cases were 32/168 (19%), IDA was 19/168 (11.3%) and 66/168 (39.3%) were normal subjects.There was a significant decrease in HB, MCH, MCV, and MCHC levels in both carriers and cases of β-thalassemia compared to non β thalassemia and IDA group.HBA2 was significantly higher in carriers compared to non β thalassemia and IDA group.Consanguineous marriages contribute to increase prevalence of β thalassemia major cases as thalassemia is an autosomal inherited disorder.Pallor was the most common clinical finding that was described in the studied group. Clinical manifestations of carriers were usually mild. Hepatosplenmegaly and blood transfusion history were less common presentations of carriers group compared to cases group.
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