الفهرس 
Iron Deficiency AnemiaOnly 14 pages are availabe for public view
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Abstract
Background: Iron plays a vital role in immune system development, integrity, as well as proper function through its growth promoting and differentiation inducing properties for immune cells and its interference with cell-mediated immune effector pathways and cytokine activities. In the last few decades, several studies found that iron deficiency is markedly affecting immune system. However, data on the effect of iron deficiency on immune function are still confusing and contradictory.
Aim of the study is to assess impact of iron deficiency anemia on cell mediated immunity.
Subjects and methods: The percentage and count of T-lymphocytes (CD3+), their CD4+, CD8+ subsets and CD4+/CD8+ ratio were evaluated in 25 iron-deficient and 15 healthy adult females. The impact of iron therapy on the same parameters was also assessed in patients after correction of anemia.
Results: In our study, there was no statistically significant difference between patient and control groups as regard CD3+, CD4+, CD8+ cell count and percentage and CD4+/CD8+ ratio with no statistically significant difference after iron therapy. However, it was found that serum ferritin level was significantly positively correlated with CD4+/CD8+ ratio, CD4+ cell percentage and absolute count and significantly negatively correlated with CD8+ cell percentage.
Conclusion: Iron deficiency has no impact on cell-mediated immunity as regard quantitative changes in T-lymphocytes subsets and CD4/CD8 ratio.