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Abstract Our study was conducted on patients in surgical oncology department and postoperative anesthesia care unit (PACU) in South Egypt Cancer Institute (SECI), Assuit University, Egypt, after obtaining Hospital Ethical Committee approval; it was prospectively registered at ―www.clinicaltrial.gov‖ under number: (NCT04375111). Written informed consent from seven forty ASA I-II female patients aged 18-60 years, weighted from 50-90 Kg and scheduled for modified radical mastectomy (MRM) breast cancer was obtained. Excluded from the study were patients with known allergy to the study drugs, significant cardiac, respiratory, renal or hepatic disease, drug or alcohol abuse, and psychiatric illness that would interfere with perception and assessment of pain. |