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Abstract Summary This study was conducted to compare the effect of delayed and early loading protocols on the stability of implants placed in the posterior maxilla after transalveolar sinus lifting with PRGF. In this study, fourteen patients were selected from the outpatient clinic of the prosthodontic department according to the inclusion and exclusion criteria. For all patients, Transalveoalr sinus lifting was performed using osteotomes. Bone graft was mixed with PRGF and introduced into the site of osteotomy and finally implant was placed. At the first stage of surgery, smart peg was screwed to the implant and ostell device was used to measure the primary stability of the implant. Patients were divided into two groups. In the first group, the prosthesis was delivered after six weeks following early loading protocol. In the second group, the final prosthesis was delivered after six months following delayed loading protocol. After six weeks, in the first group, delivery of the final prosthesis was performed and implant stability was measured again using Ostell. The measurements were repeated after three and six months after loading. In the second group, final prosthesis was delivered after 6 months following delayed loading protocol. Measurements of the implants stability using Ostell were taken at the time of loading, three and six months after loading. The recorded data was collected and tested statistically in the same group and between the two groups. The tested data revealed no significant statistical difference between the two groups. The study found that, there was no significant difference between both loading protocols regarding the effect on the stability of implants. Conclusion Within the limitations of this study, it can be concluded that early loading and delayed loading protocols may have the same effect on implant stability in maxillary implant supported removable partial dentures placed by transalveolar augmentation using PRGF . Recommendation Early loading protocol could be considered in posterior maxilla as implant stability at the time of loading was found to be acceptable. The use of PRGF has shown to reduce the healing time of implants thus allow a safer early loading. As the studies performed on early loading in posterior maxilla was found to be limited, further studies should be done with larger sample sizes |