الفهرس 
End stage renal Disease and renal replacement therapyOnly 14 pages are availabe for public view
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Abstract
Introduction: Cardiovascular disease is the most common cause of death in patients with chronic kidney disease (CKD) and vascular calcification is one of the strongest predictors of cardiovascular risk. The prevalence of vascular calcification increases as glomerular fil tration rate (GFR) declines and calcification occurs years earlier in CKD patients than in t he general population. (Palit & Kendrick, 2014).
Patients and methods: In our study we selected 50 patients ESRD maintained on hemodialysis divided into 2 groups, group 1: comprised of 25 patients maintained on hemodialysis with high flux dialyzer and group 2: comprised of 25 patients maintained on weekly session of hemodiafiltration and comparison between both groups regarding FGF23 serum level in addition to cardiovascular screening for calcifications using ECHO, Carotid intima-media thickness, and carotid duplex.
Results: we found that Post dialysis FGF23 was significantly lower in “hemodiafiltration patients” than „hemodialysis patients” and Reduction ratio was significantly higher in “hemodiafiltration patients” than „hemodialysis patients”. (P <0.001). ECHO score and carotid duplex score were insignificantly different between both groups, but carotid intima-media thickness was significantly higher in haemodialysis patients‟ group (P value 0.035). Post HDF FGF 23 had a significant positive correlation with IMT (r=0.579, P=0.008). Serum level of FGF23 post-HD and HDF had significant positive correlation with serum Calcium (r=0.659, P=0.002), (r=0.474, P=0.035) respectively, PTH (r=0.485, P=0.03), (r=547, P=0.013) respectively , CRP (r=0.646, P=0.002), (r=707, P<0.001) respectively and serum phosphorus (r=0.462, P=0.04), (r=478, P=0.033) respectively. In HD group Carotid Duplex Score had significant positive correlation with serum Ca (r=0.469, P=0.037), while in HDF group Carotid Duplex Score had significant positive correlation with PTH (r=0.59, P=0.006).
Conclusion: Using online HDF technique showed a significant reduction of FGF23 and improvement of carotid intima-media thickness calcification score