الفهرس 
Does liver diffusion tensor imaging (L-DTI) has a role in differentiation of hepatic focal lesions? Analytic study for assessment of the value of L-DTI in differentiating hepatic focal lesions according to LI-RADSm
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Abstract
Background: HCC is a major health problem worldwide and especially in Egypt. The multiphasic contrast-enhanced MRI plays an important role in the hepatic malignancy diagnosis with high specificity. Unfortunately, the contrast usage may not be feasible (i.e. renal failure) in all situations. Thus; Unenhanced MRI techniques, like DWI and DTI, may be helpful. Methods: 51 patients having 95 hepatic focal lesions has done dynamic MRI of the liver with DTI acquisition then post processing to obtain DTI-ADC and FA maps. Sequences were then assessed to obtain DWI-ADC, DTI-ADC and FA values of each studied hepatic focal lesions. The relation of LI-RADS category and lesion type to the fore-mentioned values were studied. Also; sensitivity, specificity, 95% confidence interval and cut off values were calculated for the value of usage of DWI-ADC, DTI-ADC and FA values in the differentiation of the benign and malignant lesion.Results: there is a positive moderate significant correlation between FA values and the LI-RADS category while a substantial negative significant correlation between DTI-ADC values and the LI-RADS category and a moderate negative significant correlation between DWI-ADC values and the LI-RADS category were found. Also; an overall significant difference of the FA, DTI-ADC and DWI-ADC values among the different LI-RADS categories of the studied observations as well as lesions{u2019} type were found. Finally; significant role for their using in benign and malignant lesions differentiation were found with sensitivity 87.1% and specificity 73.9% for the FA, sensitivity 88.7% and specificity 88.3% for the DTI-ADC and sensitivity 78.5% and specificity 68.7% for the DWI-ADC