الفهرس 
outcomes of pediatric-inspired chemotherapy protocol in adolescent And young adults (AYAs) suffering from acute lymphoblastic leukemia
AbstractOnly 14 pages are availabe for public view
 |  | from | 236 |  |  |
| | | from | 236 | | |
Abstract
Background: The overall survival for adolescents and young adults (AYA) with ALL continues to lag behind that of younger children. Many retrospective and prospective studies reported better outcomes with the pediatric-inspired protocols when compared to the adult protocol. {u2022} Methods: This retrospective cohort study included all patients aged more than or equal to 18 and less than 40 suffering from Acute Lymphoblastic leukemia/lymphoma (ALL/ LBL) who received treatment at Medical Oncology Department, National Cancer Institute, Cairo University in the period from January 2014 till December 2018. {u2022} Results: Through this period, 169 patients were assessed. Most of the patients (n=108) had received the mDFP protocol. Seven patients had received the Total XV protocol, while fifty-four cases had received mGMALL protocol. The pediatric-inspred regimens were well tolerated among our patients. When compared to the adultprotocol, the pediatric-inspired regimens were associated with higher DFS (33 vs 18.8 months, p=0.046), OS(26 vs 21 months, p=0.176), and CR rates (91% vs 86%, p=0.515). Also, the pediatric-inspired regimens were associated with lower incidence of septic shock during induction (24% vs 39%, p=0.013), lower incidence of early mortality (20% vs 33%, p=0.059), and shorter period of hospital stay during induction ( Mean 31 vs 40 days, p<0.001). {u2022} Conclusion: The pediatric-inspired chemotherapy regimens were well tolerated for AYA patients, and it was associated with better outcomes. Continuous sincere efforts should be paid towards improving patient{u2019} adherence to treatment and management of treatment-related adverse events