الفهرس 
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Abstract
”The objective of this work was to determine the prophylactic and chemo-sensitizing effect of BSG to enhance the Ehrlich cell’s responsiveness to Cyclophosphamide by inducing their apoptosis and inhibiting cell proliferation epithelial-mesenchymal transition (EMT), metastasis, and stemness. To accomplish this, experimental animals were divided into seven groups of 10 mice. For one month, the size of each group’s solid tumors was measured twice weekly. Tumor volume measurement demonstrated a substantial impact of BSG and/or Cyclophosphamide, indicating an inhibitory effect on cancer cell growth. There was a substantial decline in prognostic tumor markers TNFα and NF-κB in all treatment groups. BSG substantially reduced the incidence of Ehrlich cell metastasis into the lung and liver. BSG showed potent anti-cancer and chemo-sensitizing characteristics via targeting multi-signaling pathways of cancer cell proliferation, survival, metastasis, and cell stemness mediated by initially targeting Nrf2. This occurs through the up-regulation of apoptosis by targeting P53/Bax/Bcl2 pathways, down-regulation of metastasis and stemness CD44/SVV, NANOG, and SOX2 pathways, and down-regulation of drug resistance.