الفهرس 
Aim of The WorkOnly 14 pages are availabe for public view
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Abstract
Diabetes mellitus (diabetes) is a complex metabolic disorder characterized by abnormal levels of glucose (fasting glucose >7 μmol/l) in the blood. During the fed state, the pancreas Releases insulin to induce glucose uptake by the recipient cells, thus reducing the high blood glucose levels. However, during low Sugar levels, it secretes glucagon to induce liver cells to release the stored glucose, thus increasing the blood glucose concentration.
Diabetes is characterized by two subtypes: Type 1 diabetes (T1D), which is insulin dependent, and Type 2 diabetes (T2D), which is insulin independent.
MiRNAs are estimated to regulate the expression of more than 60% of protein-coding genes; consequently, changes in their expressions have been linked to many diseases, including cancer, endocrine disorders and autoimmune diseases. Growing evidence suggests that miRNAs also play a key role in immune system functions as well as in beta-cell metabolism, proliferation and death, which are processes involved in T1DM pathogenesis .MiRNA-specific profiles were observed in PBMCs or serum from T1DM patients, and some miRNAs seem to modulate mRNA expressions of the major T1DM autoantigens
Aim of the work:
The aim of this study was to highlight Micro RNA as biomarker for Type 1 Diabetes and their relevance of glycemic control.