الفهرس 
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Abstract
The main objective of this study was to investigate the efficiency of cod liver and flaxseed oils as protective and curative agents on fructose–induced fatty liver disease. The study was conducted using 60 adult male albino rats of Sprague Dawley strain which were randomly divided into two experiments, namely protective and curative experiments. In protective experiment, 30 rats were divided into 5 equal groups including normal (- control) group, untreated HFD -fed (+ control) group besides 3 groups fed on HFD containing 10% of either cod liver oil, flaxseed oil or their equal mixture for 4 weeks. In curative experiment, 30 rats were divided into 5 equal groups including normal (- control) group, untreated fatty liver diseased (+ control) group besides 3 fatty liver diseased groups fed on basal diet containing 10% of either cod liver oil, flaxseed oil or their equal mixture for 4 weeks. To be fatty liver diseased, rats were previously fed on HFD ””50% fructose”” for 4 weeks. Results of both experiments showed that HFD led to a significant elevation in body weight gain %, feed efficiency ratio, the relative weights of liver, kidneys and heart, the activities of transaminases and alkaline phosphatase in serum as well as serum levels of creatinine, urea nitrogen and uric acid besides the levels of tumor necrosis factor alpha, malondialdehyde and nitric oxide in liver tissue homogenate, while serum proteins were significantly reduced. In addition, abnormal changes were noticed in liver tissue. In general, the chemical analysis of cod liver and flaxseed oils supports the abundance of omega 3 fatty acids in them, especially DHA and EPA in cod liver oil and alpha- linolenic acid in flaxseed oil, which resulted in marked antioxidant and anti-inflammatory properties which in turn led to hepatoprotective and hepatocurative effects. Finally, the current study recommends avoiding fructose rich sources and supplementing the daily meals with cod liver and flaxseed oils singly or as a mixture to prevent fatty liver disease and by patients with this disease in order to alleviate it.