الفهرس 
U LCERATIVE C OLITISOnly 14 pages are availabe for public view
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Abstract
Abstract
Background
Ulcerative colitis is a chronic condition of unknown etiology that causes widespread inflammation of colonic and rectal mucosa and is characterized by attacks of relapse and remission. The diagnosis is based on a combination of symptoms, endoscopy and histopathology. Induction and maintenance of clinical and endoscopic remission is the target of UC treatment protocols. Serum biomarkers are used as inflammatory markers that monitor the disease activity and determine the need for invasive tests. IL-21 is involved in pathogenesis in many autoimmune condition such SLE and RA. In this study, we are going to study the correlation of serum IL-21 with mucosal and laboratory remission in Egyptian Ulcerative Colitis patients.
RESULTS
The level of IL-21 was higher in the active ulcerative colitis group than the remission group and also was higher in the remission group than the control group. IL-21 level was higher in severe activity UC patients than moderate activity UC patients. There was also a statistically significant difference in the level of TLC, CRP and ESR in the active ulcerative colitis group than the control and the remission groups. The best cut off point found between remission group and UC active group regarding IL-21 is found > 131 pg/ml with sensitivity of 100.0%, specificity of 100.0% and area under curve (AUC) of 100%.
The best cut off point found between moderate UC group and severe UC group regarding IL-21 was > 188.8 pg/ml with sensitivity of 85.71%, specificity of 100.0%.
CONCLUSION
IL-21 can be used as a biomarker for diagnosis of Ulcerative colitis and also as a biomarker to assess severity and activity of the disease.