الفهرس 
Hepatitis C VirusOnly 14 pages are availabe for public view
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Abstract
Abstract
Hepatitis C virus infection a leading cause of liver cirrhosis, has a significant global impact, where it infects about 71 million in 2015 with highest prevalence in the Eastern Mediterranean and European regions, According to WHO. In Egypt it is 10% prevalent before the National Campaign done in 2018-2019.
The aim of this study is to evaluate the role of Resistin in detecting Insulin Resistance and their impact on response to direct acting antiviral in chronic hepatitis C patients.
It’s well-known that Hepatitis C virus infection is considered a systemic disease, and among extra-hepatic manifestations, insulin resistance and diabetes are reported to be associated with high frequency to the infection.
The aim of this study is to evaluate the role of Resistin in detecting Insulin Resistance and their impact on response to direct acting antiviral in chronic hepatitis C patients.
This prospective Cohort clinical study was conducted on40 Egyptian patients who were ≥18years of age having chronic viral hepatitis C and 10 healthy control, recruited from Ain shams university hospital center for treatment of viral hepatitis.
Also comparison between the two groups as regards FBS, Fasting Insulin Level, HOMA-IR equation and Serum Resistin Level pre-treatment and post-treatment, in the Naïve group with which shows statistical significance being higher in naïve and relapser pre-treatment with P-value <0.001 in both groups.