الفهرس 
Materials & MethodsOnly 14 pages are availabe for public view
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Abstract
The present study was designed, aiming at highlighting the effect of ginger and saffron extracts on the growth of transplanted Ehrlich ascites carcinoma (EAC) in female mice after 4 weeks of inoculation and in vitro experimentation.120 mg/kg body weight (ginger),100 mg/kg body weight (saffron) were the effective doses used during experimentation, because of inducing more regression in the tumor volumes. Mice were divided into six groups; normal control mice, mice-bearing solid tumor without treatment and others treated with the effective doses of ginger and saffron extracts respectively and normal mice treated with the effective dose of ginger and saffron extracts. This investigation discussed the role of ginger and saffron in defeating induced solid tumours with the subcutaneous inoculation of mice with Ehrlich ascites carcinoma (EAC) in a definite volume (3X106 cells). Once the tumours were formed, the mice were divided into six groups(control, tumour untreated, ginger, saffron, ginger treated, saffron treated) groups. Each group contains ten mice. By the end of experimentation (4 weeks); after tumour formation, mice were dissected and histological examination for liver and kidney were performed in all groups. Also, the levels of liver functions (ALT & AST), kidney functions (Urea & Creatinine), an oxidation compound (MDA), antioxidant enzymes (SOD & CAT) and DNA patterns in tumour, liver and kidney tissues; were measured in all tested groups. This study could state that ginger and saffron modulated the histological structures of both liver and kidney close to normal patterns and ameliorated the fragmentation of DNA induced with EAC inoculation to be near of normal patterns. Also, treatments could modify the elevated values of (ALT, AST, Urea, Creatinine and MDA) and decreased levels of (SOD and CAT) towards the normal values. Treatments with ginger and saffron also reduced the tumour volumes significantly.
Key Words: ginger, saffron, liver, kidney, Ehrlich ascites carcinoma (EAC), solid tumour, in vitro