الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
Hepatitis C is a common world liver disease caused by hepatitis C virus
(HCV) which can cause both acute and chronic hepatitis, ranging in severity from
a mild illness lasting a few weeks to a serious, lifelong illness. Sofosbuvir (sofo) is
a nucleotide prodrug for treatment of HCV. It is a selective inhibitor of the HCV-
NS5B polymerase. Although sofo has an effective potential in reducing HCV load,
its use was accompanied with some side effects on mammalian organs.
Few decades ago, medicinal plants are widely used throughout the world due
to their potent pharmacological activities, low toxicity and economic viability
comparing with the synthetic drugs. Moringa oleifera (MO) tree is one of these
plants which have medicinal and nutritional properties for both human and
animals. Most of MO parts (root, bark, gum, leaves, pods, flowers and seeds) have
many functional bioactive compounds including phenolics, flavonoids,
antioxidants, sterols, tocopherols and fatty acids.
The present work was designed to evaluate the histological, ultrastructural,
immunohistochemical and biochemical toxicity of sofo treatment on the renal
cortex of adult male albino rats and the possible ameliorative role of MO oil.