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Abstract while the other 19 patients (56 %) developed respiratory distress and received NPPV. 8 patients were diagnosed with VAP and 7 of them failed to respond to NPPV within the 48 hours post-extubation, and were re-intubated. Conclusion: Based on the higher rate of successful weaning, shorter duration of invasive ventilation, shorter ICU length of stay and lower incidence of VAP, implementation of the PIC window as an optimal switching point for application of NPPV during weaning of IMV, has proven to be a more promising weaning modality than conventional weaning strategies |