الفهرس 
Association of miRNA-196a2 rs11614913 and miRNA-499 rs3746444 single nucleotide polymorphisms with susceptibility to Behc?et{u2019}s disease /
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Abstract
Background: Behçet{u2019}s disease (BD) is a chronic, systemic, inflammatory disorder characterized by recurrent uveitis, oral & genital ulcers & skin lesions. MicroRNAs (mi-RNAs) are 20{u2013}22 nucleotides long, small non-coding RNAs that regulate gene expression post-transcriptionally. They play a role in inflammatory and immune- mediated diseases. Single nucleotide polymorphisms (SNPs) may be implicated in altered expression or biological functions of mature mi-RNAs. Subjects and methods: The aim of the current study was to determine the genotypes of miR-196a2 rs11614913 C>T & miR-499 rs3746444 A>G in an Egyptian cohort with BD to find out their possible association with BD susceptibility, clinical manifestations and disease activity.The analysis of the polymorphisms was performed using TaqMan allelic discrimination assay. Results: Apart from significantly increased frequency of the TT genotype compared with the CC + CT genotypes in patients compared to control subjects (p= 0.045), no difference was observed in the distribution of miR-196a-2 genotypes and alleles between patients and controls. Among the studied demographic features, patients with rs11614913 CT genotype had a higher mean age at disease onset (29.1 ± 9.3 years) compared with the CC and TT genotypes (23.6 ± 7.2 and 25.5 ± 9.5 years, respectively) (p= 0.02). Among the studied clinical features, patients with neurological manifestations had a higher frequency of the CT + CC genotypes as opposed to their absence in patients carrying the TT genotype (p = 0.02)